Neuroplex, a novel imaging pipeline, enables simultaneous measurements of the activity of up to nine identified brain cell types in living mice, up from the previously established standard of two.

Understanding the packing and folding of DNA in sperm cells is a fundamental question in modern biology, related to infertility and to genetic and developmental defects. UC Davis researchers have now unveiled an important new piece of this puzzle. They have identified a protein, called DAXX, that guides how sperm DNA is organized, silences numerous genes and keeps some switched on. The work was published recently in Genes & Development. 

A new Thought Leaders invited review in Genomic Psychiatry synthesizes more than two decades of work on HuD, a neuronal RNA-binding protein encoded by the ELAVL4 gene. Drawing on RIP-seq and CLIP-seq data from embryonic and adult mouse brain, the authors compare close to 4,000 HuD-bound messenger RNAs and identify 1,926 shared targets. Despite different molecular casts at different ages, fifteen canonical pathways and thirty-one disease and function categories recur across development and maturity. The synthesis suggests that adult neuronal plasticity is, at the molecular level, a recapitulation of early development.A new Thought Leaders invited review in Genomic Psychiatry synthesizes more than two decades of work on HuD, a neuronal RNA-binding protein encoded by the ELAVL4 gene. Drawing on RIP-seq and CLIP-seq data from embryonic and adult mouse brain, the authors compare close to 4,000 HuD-bound messenger RNAs and identify 1,926 shared targets. Despite different molecular casts at different ages, fifteen canonical pathways and thirty-one disease and function categories recur across development and maturity. The synthesis suggests that adult neuronal plasticity is, at the molecular level, a recapitulation of early development.A new Thought Leaders invited review in Genomic Psychiatry synthesizes more than two decades of work on HuD, a neuronal RNA-binding protein encoded by the ELAVL4 gene. Drawing on RIP-seq and CLIP-seq data from embryonic and adult mouse brain, the authors compare close to 4,000 HuD-bound messenger RNAs and identify 1,926 shared targets. Despite different molecular casts at different ages, fifteen canonical pathways and thirty-one disease and function categories recur across development and maturity. The synthesis suggests that adult neuronal plasticity is, at the molecular level, a recapitulation of early development.