While the U.S. has recently seen a welcome downturn in drug overdose deaths, a new study from Northwestern Medicine is the first to pinpoint when the tide began to turn — identifying August 2023 as the national inflection point in the crisis.

Researchers at Michigan Medicine uncovered a key mechanism that regulates blood pressure and vascular remodeling — increasing downstream risk of heart attack and stroke — in people with a genetic variant linked to high blood pressure, a study in both animals and human samples suggests. The findings may guide clinicians toward personalized management of hypertension for some patients