Researchers blocked a naturally occurring molecule to reverse pulmonary arterial hypertension in preclinical models, a finding that could point to a new treatment approach for people with a rare and often fatal lung disease. Scientists said more work is needed to determine whether targeting the molecule would be safe and effective in people.

KRAS inhibitors shrank existing NF1-related nerve tumors and prevented new tumors from forming in a mouse model that closely mirrors the human disease, according to new research led by experts at Cincinnati Children's.

Recent research has pointed to bone marrow found in the skull as an important site of communication between the brain and the immune system.

MUSC startup OncoBLAZE is developing a new imaging system that could help cancer researchers see experiments unfold in real time. Created by Hollings researcher Dieter Haemmerich, Ph.D., SphynxVision uses fluorescence imaging to track cancer cells, drugs and other biological processes under normal room lighting. Unlike conventional systems that require samples to be placed inside dark, closed chambers, its open design allows researchers to perform procedures while continuously capturing high-resolution images. The technology grew out of Haemmerich’s own need to track chemotherapy as it was delivered to tumors and could ultimately help scientists uncover biological changes that current imaging systems miss. OncoBLAZE is now preparing to place early versions of SphynxVision in research laboratories for testing ahead of a broader commercial launch.