LDIR treatment induces axonal sprouting, brain rewiring and EEG oscillatory activity two months after ischemic stroke (IMAGE)
Caption
LDIR treatment induces axonal sprouting, brain rewiring and EEG oscillatory activity two months after ischemic stroke. (A) In X-ray-irradiated mice, a significant portion of axonal projections crossed the midline into the contralesional motor cortex. (B and C) Three-dimensional reconstruction of individual axonal projections revealed a significant number of neuronal projections in X-ray-irradiated mice two months after stroke. (D) EEG signals were recorded in both injured (red circle) and uninjured (yellow circle) cortices simultaneously in freely moving mice. (E) EEG activity was barely detectable in sham-irradiated mice two months after ischemic stroke. In contrast, brain activity markedly increased in X-ray-irradiated mice.
Credit
Au, N. P. et al., https://doi.org/10.1016/j.bbi.2023.09.015
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