Future design of clinical trials within TNMB staging system (IMAGE)
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Clinical trials in treatment and prognosis follow a three-step strategy: Firstly, ctDNA is assessed after completion of standardized treatment to compare experimental and SOC in ctDNA-positive and ctDNA-negative groups. Secondly, upon obtaining a positive result, the experimental treatment is compared between SOC and strategy based on MRD status, which has also been gradually validated through clinical studies in recent years. Building upon this foundation, researchers propose a third step to guide clinical study design according to TNMB staging.
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