Figure 2. 19F-NMR spectra of A2AR (IMAGE)

Tokyo Institute of Technology

Figure 2. 19F-NMR spectra of A2AR

Caption

19F-NMR spectra of A2AR (red box) identifies two activation states (orange peaks on left) used to couple to cognate (Gs) and one state (blue peak on left) to non-cognate (Go) G proteins (TM6) while TM7 labeling reveals dynamic differences (right peaks) between Gs and Go bound A2AR. Dual TM6 activation states enable greater diversity of coupling partners while TM7 dynamics dictates coupling efficacy.

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Nature Chemical Biology

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