FIGURE (IMAGE)

Institute for Integrated Cell-Material Sciences, Kyoto University

FIGURE

Caption

In normal cells (left), calcium activates the Tmem63b/Slc19a2 complex, leading to controlled phospholipid scrambling, along with Kcnn4 activation. In Tmem63b mutant (derived from human patients) cells (right), continuous phospholipid scrambling occurs without calcium stimulation.

 

Credit

H Niu, M Maruoka, Y Noguchi, H Kosako, and J Suzuki

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