Hypothesis on the Balance of Acetylcholine Signaling during Nicotine Withdrawal (IMAGE)

National Research Council of Science & Technology

Hypothesis on the Balance of Acetylcholine Signaling during Nicotine Withdrawal

Caption

(Left) Nicotine withdrawal reduces nicotinic receptor activity, leading to a relative increase in muscarinic receptor activity and disrupting acetylcholine signaling balance.
(Right) Suppressing striatal cholinergic interneurons or administering the muscarinic antagonist Procyclidine reduces acetylcholine release or inhibits muscarinic receptors. This action restores the balance of acetylcholine signaling by reducing the excessive muscarinic receptor activity.

Credit

Korea Institute of Science and Technology

Usage Restrictions

The sources of photos and research results from KIST must be specified.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.