fig 2 (IMAGE)
Caption
Major signaling pathways associated with GATA6 and pancreas. Wnt antagonist dickkopf1 (DKK1) is a target gene of GATA6, and GATA6 can promote the development and carcinogenesis of the pancreas by activating the Wnt pathway via repressing of DKK1. GATA6 can also regulate the pancreatic endoderm specification through hedgehog signaling by inhibiting sonic hedgehog (Shh), in company with GATA4. GATA6 is the downstream target of the transforming growth factor-β (TGF-β) pathway, and the expression changes of GATA6 can affect the differentiation of pancreatic cells and the self-renewal of pancreas progenitor. In addition, GATA6 can affect the maintenance of intestinal epithelial and goblet cell differentiation by regulating Notch signaling. GATA6 regulates the lymphatic dissemination of bladder cancer through vascular endothelial growth factor receptor (VEGFR) signaling, which may also be associated with the initiation and progression of pancreatic cancer.
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