Therapeutic strategies for cancer-based on redox regulation (IMAGE)
Caption
A variety of strategies have been designed to modulate redox levels. Chemotherapy, radiotherapy, and nanoparticles that generate ROS result in oxidative damage and immunogenic cell death at tumor sites, producing and releasing antigens. Covalent inhibitors facilitate the formation of neoantigens in cancer cells, which stimulates T cell responses and activates anti-tumor T cells. Furthermore, regulating ROS levels can enhance the activation of engineered T cells and inhibit immune checkpoint signaling, resulting in stronger T cell responses and, ultimately better therapeutic outcomes. Overall, these strategies highlight the potential of redox modulation in cancer therapy to strengthen immune responses against tumors.
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The corresponding author Dr. Na Xie
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