Large-Scale Functional Genomics in Tomato Using a High-Throughput Multi-targeted CRISPR Screening Approach. (IMAGE)

Tel-Aviv University

Large-Scale Functional Genomics in Tomato Using a High-Throughput Multi-targeted CRISPR Screening Approach.

Caption

The tomato plant genome is divided into gene families. For each group of similar genes, a unique CRISPR unit is designed to alter their function (in total, over 15,000 CRISPR units were designed). These CRISPR units are delivered into tomato plants, which are then monitored for growth and development. In the final stage, plants exhibiting changes in selected traits are identified and genetically and physiologically characterized. This new approach enables the large-scale targeting of genetic redundancy within gene families, on the scale of hundreds of genes.

Credit

Tel Aviv University

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