Comparison of synaptic strength during sleep and wakefulness (Firing rate in wakefulness = Firing rate in sleep) (IMAGE)
Caption
(A) For each synaptic learning rule, the distribution of the change in synaptic strength (after / before) across 1,000 different parameter sets. The “lag” refers to the time difference between the firing of the presynaptic neuron and the postsynaptic neuron.
(B) For each synaptic learning rule and firing rate (i.e., the average firing frequency in the 11-neuron network shown in Figure 1), we calculated the temporal changes in synaptic connections during sleep and during wakefulness and then compared their mean values. Under the Hebbian and STDP rule, synaptic connections are strengthened during sleep compared to wakefulness. The difference is larger especially at lower firing rate of the neural network.
Credit
Fukuaki Kinoshita / Systems Pharmacology, University of Tokyo
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