Myeloid cell phenotypes in JIA and HC PBMCs. (IMAGE)
Caption
(A, B) UMAP projection of CD4+ T cells. The dots represent single cells with colors representing cell types. (C) Violin plots of distributions of expression of cell markers in the four clusters. (D) Monocle3 assessment of pseudotime reconstructions and developmental trajectories of myeloid cells in PBMCs. (E–G) Relative proportions of cell subtypes in PBMCs in each condition. (H–J) Gene ontology enrichment analysis of highly variable genes for classical monocytes (H), intermediate monocytes (I), and non-classical monocytes (J). (K) Heatmap of gene expression changes with pseudotime trajectories. (L) Expression changes of marker genes for myeloid cells with pseudotime trajectories. PBMCs, peripheral blood mononuclear cells; JIA, juvenile idiopathic arthritis; HC, healthy control.
Credit
Genes & Diseases
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