A proposed model explaining the biological function of C1orf122 in the progression of HCC. (IMAGE)

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A proposed model explaining the biological function of C1orf122 in the progression of HCC.

Caption

C1orf122 binds to SRPK1 and mediates SRPK1 phosphorylation at the Thr601 site. This activates the PI3K/AKT/GSK3β via SRPK1, ultimately promoting the progression of HCC.

Credit

Jing Cai, Li Rong, Runzhi Wang, Zaikuan Zhang, Haiming Sun, Juan Chen, Dunchu Weng, Xinyi Li, Xiaosong Feng, Peiyi Lin, Shengming Xu, Zhihong Jiang, Yajun Xie, Qin Zhou

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CC BY-NC-ND

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