Working model of de novo glycine metabolism and the activation of collagen synthesis in colorectal cancer‐cancer‐associated fibroblasts (CRC‐CAFs). (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Working model of de novo glycine metabolism and the activation of collagen synthesis in colorectal cancer‐cancer‐associated fibroblasts (CRC‐CAFs).

Caption

A working model showing that CAFs exhibit profound amino acid reprogramming, especially the production of glycine, in CRC. CRC cell‐derived TGF‐β1 activates de novo glycine synthesis in CAFs, promoting collagen production. The pharmacological inhibition of PHGDH, the rate‐limiting enzyme of the de novo glycine synthesis pathway, significantly attenuated collagen production in CAFs, providing a potential strategy for treating CRC.

Credit

Yinglan Zhao & Xiao Du

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