Biased modulator graphic (IMAGE)

Sanford Burnham Prebys

Biased modulator graphic

Caption

Understanding what causes a compound to be a biased modulator is a key step in enabling the design of compounds with more precision in the array of G proteins that they activate. The scientists demonstrated that SBI-553 biases NTSR1 signaling by acting as a molecular bumper for some of the G proteins and as molecular glue for others.

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Behnoush Hajian, PhD | Sanford Burnham Prebys

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