Molecular mechanisms of integrin-mediated actin remodeling in tumor invasion. (IMAGE)
Caption
The components of the actin complex in focal adhesions and invadopodia are similar, but their assembly, structure, and functions are completely different. Actin stress fibers are anchored to the plasma membrane at the integrin-dependent focal adhesions parallel to the extracellular matrix (ECM) (A), in contrast, the actin core in invadopodia is oriented perpendicular to the ECM and cell membrane (B). Invadopodia are built on a Tks5/Nck/WIP/N-WASP-dependent branched actin network, and Rho GTPase and Cdc42 drive pseudopodia-membrane protrusion, which is mediated by bundled actin filaments that form the actin core as the initial step in invadopodia assembly.
Credit
Chenhe Liu, Shijiang Wang, Xin Zhang, Yifan Han, Min Tan, Jiehou Fan, Jing Du, Yubo Fan, Xinbin Zhao
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CC BY-NC-ND