Joint association of age at diabetes diagnosis and APOE ε4 carrier status with risk of ACD. (IMAGE)
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(A) HRs for ACD based on combinations of age at diabetes diagnosis and APOE ε4 status. Participants without APOE ε4 and diagnosed after age 60 served as the reference. (B) Association between age at diagnosis and ACD risk within each APOE ε4 subgroup. Cox models were adjusted for age, sex, ethnicity, BMI, TDI, education, smoking, alcohol consumption, stroke, MI, and hypertension. APOE ε4: apolipoprotein E ε4 allele.
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