Normal and bi-lobed embryo (IMAGE)

Institute of Science and Technology Austria

Normal and bi-lobed embryo

Caption

Embryo representation. At the top is a normal embryo with a single lobe, which is a hemispherical cluster of cells (shown in different colors). The cells near the top of this lobe are usually the largest, and this is where the mitotic waves begin. Below is a bi-lobed embryo, which is the result of a mechanically manipulated zygote, resulting in two lobes and consequently two mitotic waves. When Mishra first observed this during his postdoctoral research, he considered it a groundbreaking moment. 

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© Nikhil Mishra / ISTA

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