Figure 3 (IMAGE)

Institute for Basic Science

Figure 3

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The synthetic biological circuit of the noise controller. In the biological circuitry of the conventional control mechanism, the final output (X2) produces an anti-sigma factor (RsiW), which binds to the sigma factor (SigW) responsible for generating the system’s input (X1). The Noise Controller uses a similar anti-sigma/sigma interaction—specifically, between the anti-sigma factor RseA and the sigma factor ECF. However, it differs in two key aspects: the anti-sigma factor is produced through a dimerization reaction of the final output (X2), and this anti-sigma factor directly degrades the system’s input (X1).

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Institute for Basic Science

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