Figure 1 (IMAGE)

Nano Life Science Institute (NanoLSI), Kanazawa University

Figure 1

Caption

HGF-induced Met dimerization. The AlphaFold3-predicted structure of Met (A). Schematics of full-length Met purification (B). SDS-PAGE and silver staining of purified full-length Met (C). HS-AFM images of full-length Met on mica (D). HS-AFM images of 2:2 HGF-Met complex isolated from living cells (E). Normal mode flexible fitting of the atomistic model of the HGF-Sema structure to the HS-AFM image (F). Split-luciferase complementary assay demonstrating HGF-induced Met dimerization at IPT4 domain (G). Molecular model of an IPT4 dimer (H).

Credit

Adapted with permission from ACS Nano 2025, 19 (48), 40746–40758. © 2025 American Chemical Society.

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