PROTACs and E3 ligases (IMAGE)

Goethe University Frankfurt

PROTACs and E3 ligases

Caption

PROTACs link a target protein (protein of interest, POI) with an E3 ligase, which mediates the ubiquitin labeling (yellow) of the POI via an E2 enzyme. The POI is then degraded in the proteasome shredder (blue).

Credit

Institute of Biochemistry II, Goethe University Frankfurt

Usage Restrictions

To be used only when reporting on Goethe University Frankfurt. Credit Institute of Biochemistry II, Goethe University Frankfurt

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