UBR5 was a favorable prognostic factor in human colorectal cancer. (IMAGE)
Caption
(A) Snail was highly expressed in samples obtained from patients with colorectal cancer. Immunohistochemical analysis of Snail expression levels in normal colorectum and tumors in the Human Protein Atlas website. Representative images are shown. ∗∗∗P < 0.001; student's t-test.
(B) GEPIA revealed that UBR5 had higher expression in normal tissue samples compared with tumor samples. Dark and light gray indicate tumor and normal tissues, respectively.
(C) High expression of UBR5 was associated with a favorable prognosis. Kaplan–Meier analysis of 20-year overall survival of rectum adenocarcinoma cancer patients with UBR5 (n = 165). Log-rank P-values are shown.
(D) Diagram of the pattern of UBR5 regulation of epithelial–mesenchymal transition (EMT) in colorectal cancer. UBR5 inhibited the invasive migration of tumor cells by regulating the ubiquitination and transcriptional activity of Snail, and UBR5 C2768S eliminated the inhibitory effect of UBR5 on EMT.
Credit
Xinyue Zhao, Ruiying Liu, Zhihui Han, Zehao Li, Ling Mei, Yuyang Liu, Xueqi Fu, Yue Jin
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