Analysis and confirmation of the differentially expressed mRNAs in the KO and WT EIU groups (IMAGE)
Caption
(A) Principal component analysis of retinal mRNA expression levels in the KO EIU and WT EIU groups. The distribution of dots indicates distinct mRNA expression patterns between KO EIU and WT EIU. (B) Volcano plot of total mRNAs. The red, blue, and gray dots represent up-regulated, down-regulated, and non-significantly altered mRNAs, respectively. The data at infinity are not shown. (C) Hierarchical clustering heatmap analysis of differentially expressed mRNAs. The red represents increased expression, and the blue represents decreased expression. (D–F) GO enrichment analysis of co-expressed mRNA targets, covering biological processes, cellular components, and molecular functions. The top 10 GO terms of each domain are shown. WT, wild type; KO, Cgas knockout; NC, normal control; EIU, endotoxin-induced uveitis; GO, gene ontology.
Credit
Yue Guo, Ruiping Gu, Jiaojiao Wei, Chunhui Jiang
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