Schematic representation of MDK alleviating bone loss (IMAGE)
Caption
MDK is significantly elevated in the serum of postmenopausal osteoporotic women and ovariectomized mice. Due to estrogen deficiency, iMDK alleviates bone loss by promoting bone formation and inhibiting inflammatory factors. Recombinant MDK protein inhibits osteogenic differentiation through the PI3K/AKT signaling pathway and up-regulates inflammatory factors IL-6, TNF-α, and IL-1β via the NF-κB signaling pathway.
Credit
Xieyidai Ruze, Yutong Hu, Xiongyi Wang, Houfu Lai, Ruizhi Zhang, Sheng Pan, Jiajun Zhang, Yike Wang, Simin Yun, Ying Xu, Junjie Li, Youjia Xu
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Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND