There is a negative correlation between serum MDK levels and BMD (IMAGE)
Caption
(A) Schematic of the experimental workflow for detecting MDK expression in postmenopausal osteoporosis and in ovariectomized mice. (B) Statistical analysis of T-score differences between hip and lumbar spine BMD in patients (Normal-BMD vs. OP groups). Inter-group comparisons were analyzed by the Wilcoxon signed-rank test. (C) Serum MDK protein concentrations were measured using ELISA. Inter-group comparisons were analyzed by a two-tailed unpaired Student's t-test (for normally distributed data with equal variance). Normal BMD: normal bone mineral density group (n = 42); OP, osteoporosis group (n = 42). (D, E) Pearson correlation analysis of the relationship between serum MDK concentration and hip BMD T-score (D) and lumbar BMD T-score (E). (F) Serum MDK protein concentrations in control and OVX mice were measured using ELISA. Inter-group comparisons were analyzed by a two-tailed unpaired Student's t-test (for normally distributed data with equal variance). (G, H) Detection and quantitative analysis of MDK protein expression in bone sections of control and OVX mice using immunofluorescence. Inter-group comparisons were analyzed by a two-tailed unpaired Student's t-test (for normally distributed data with equal variance). Scale bar, 100 μm ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗∗p < 0.0001.
Credit
Xieyidai Ruze, Yutong Hu, Xiongyi Wang, Houfu Lai, Ruizhi Zhang, Sheng Pan, Jiajun Zhang, Yike Wang, Simin Yun, Ying Xu, Junjie Li, Youjia Xu
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