(IMAGE)

Institute for Glyco-core Research (iGCORE), Tokai National Higher Education and Research System

Caption

Brain-specific enzyme MGAT5B modifies neurofascin 186 with branched O-mannose glycans, helping maintain the narrow structure of nodes of Ranvier. Loss of these sugar branches broadens the nodes, slowing nerve conduction, increasing variability in signal transmission and affecting motor coordination.

Credit

Gifu University, Created in BioRender. Kizuka, Y. (2026) https://BioRender.com/wuapa3d

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