C3 protein in tumors helps cancer immunotherapy work (IMAGE)

Nagoya University

C3 protein in tumors helps cancer immunotherapy work

Caption

C3 made locally by fibroblasts in the tumor keeps harmful myeloid cells out and helps immunotherapy work (left). Without this local C3, these cells build up, making tumors resistant to treatment (middle). C3 circulating in the blood, made by the liver, has no effect in either situation (right). 
 

Credit

Miyai et al., Nature Communications, 2026

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CC BY

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