Figure 2. Structural transition between the two conformational states of the human norovirus VLP (IMAGE)

National Institutes of Natural Sciences

Figure 2. Structural transition between the two conformational states of the human norovirus VLP

Caption

In the "resting" state, the P domain is held close to the shell through intermolecular interactions (red asterisk) between the P2 subdomains of neighboring capsid proteins. In the "rising" state, the P domain rotates and moves upward, and these interactions are replaced by new intermolecular contacts (red asterisk) between the P1 subdomains, which stabilize the elevated conformation.

Credit

Kazuyoshi Murata

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