KAIST Develops a Strategy to Balance Radical Generation and Catalyst Regeneration, Enabling Challenging Chemical Reactions (IMAGE)
Caption
Figure 3. Reaction and Mechanism for 3,3-Disubstituted Oxindole Synthesis Using a Cyclopropenimine-Copper Catalyst
Shows the reaction and mechanism for synthesizing 3,3-disubstituted oxindoles from tertiary alkyl halides using a copper catalyst bound to a cyclopropenimine ligand. Tertiary alkyl bromides react at room temperature, and the method can even be applied to tertiary alkyl chlorides, which are difficult to activate. It can be applied to a range of substrates to synthesize 3,3-disubstituted oxindoles in high yield, and tertiary alkyl bromides react even at room temperature while the method extends to tertiary alkyl chlorides, which are difficult to activate.
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