Plasma Metabolites for Identifying Bacterial Infection in Acute-on-chronic Liver Failure (IMAGE)

Xia & He Publishing Inc.

Plasma Metabolites for Identifying Bacterial Infection in Acute-on-chronic Liver Failure

Caption

This study delineated the metabolic landscape of AoCLD associated with bacterial infection. Based on novel metabolite biomarkers, we developed diagnostic models for bacterial infection tailored to the ACLF disease spectrum. These models outperformed conventional indicators. A risk stratification strategy based on baseline metabolic perturbations can indicate the risk of 90-day outcomes. Plasma metabolic biomarkers in these models may serve as reference indicators to enhance precise diagnosis and personalized management in patients with AoCLD.

Credit

Xin Zheng, Lining Guo

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License

CC BY-NC

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