Figure 2. Conceptual model of proposed routes within the putative craniomaxillary–brain interface. (IMAGE)
Caption
Figure 2: Building on the established calvarial evidence summarized in Figure 1, this figure illustrates hypothetical mechanisms by which craniomaxillary tissues may communicate with CNS-border compartments. Dashed lines indicate proposed connections lacking direct anatomical evidence, whereas solid elements denote established relationships within individual compartments and do not imply continuous maxillary- or mandibular-meningeal pathways. Putative local skeletal or vascular route marrow-linked routes from the maxilla or mandible to CNS-border compartments remain hypothetical and require anatomical and functional validation.
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Ziwen Sheng, Yulong Zhang, Hao Wang, Wenyu Zhen, Youming Zhu*, Haitao Wang*, Hengguo Zhang*
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