Molecular movie of penicillin biosynthesis (IMAGE)
Caption
Short caption: Artistic concept of the ‘molecular movie’ method used to deduce how penicillin is made.
Extended caption: Molecular movie of penicillin biosynthesis. X-ray free electron laser experiments on isopenicillin N synthase microcrystals capture structural snapshots of key intermediates during the penicillin forming reaction. The film strip illustrates progression through the catalytic cycle, with the monocyclic β-lactam intermediate and reactive high valent ferryl iron species highlighted at the centre of the molecular movie.
Image credit: University of Oxford/Greg Stewart/SLAC National Accelerator Laboratory.
Credit
University of Oxford/Greg Stewart/SLAC National Accelerator Laboratory.
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