DsbA-L Protects Lung Functions (IMAGE)

Kumamoto University

DsbA-L Protects Lung Functions

Caption

DsbA-L works through various tissues to protect lung function. Epidemiological studies have shown that DsbA-L activates adiponectin, a protein that enhances lung function in adipocytes, and has an antioxidant effect in blood to reduce oxidative stress that is harmful to lung function. Studies with human lung epithelial cells have shown that DsbA-L exerts a direct antioxidant effect in lung tissue and suppresses mucus production.

Credit

Assoc. Prof. Tsuyoshi Shuto and Assist. Prof. Kentaro Oniki

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<p>From fig. 6 of Oniki, K., Nohara, H., Nakashima, R., Obata, Y., Muto, N., Sakamoto, Y., ... Saruwatari, J. (2020). The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties. Scientific Reports. doi:10.1038/s41598-020-62872-5. </p> <p>This image is made available under the terms of <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>. Any further distribution of this work must follow the terms of this license.</p>

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