How Membrane Receptors are Blocked (IMAGE)

University of the Basque Country

How Membrane Receptors are Blocked

Caption

The activation of the intracellular signalling of the IFN-gR receptor depends on the lipid nanodomains present in the membrane. The alteration of these nanodomains or the presence of a single mutation in the receptor induces galectin binding. The receptor ends up trapped in the actin filaments and cell signalling is blocked.

Credit

Instituto Biofisika (UPV/EHU, CSIC)

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