Development of neurons with and without genetic mutation associated with schizophrenia (VIDEO)

University of Tokyo

Caption

Researchers recorded 10 seconds of the growth of healthy brain neurons (kif3b+/+, top left) and neurons with a genetic mutation associated with schizophrenia (kif3b+/-, top right). Cyan or blue color marks microtubules, a component of the cell skeleton. Pink color marks another component, filamentous actin. Healthy cells show dynamic, spiky movement of actin and distinct separation between actin and microtubules. Providing mutant cells with supplemental betaine (kif3b+/-, bottom right restores normal movement and structure. Betaine seems to have no effect on healthy cells (kif3b+/+, bottom left).

Credit

Video by N. Hirokawa, CC BY, first published in Cell Reports DOI 10.1016/j.celrep.2021.108971

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Please include a Creative Commons By Attribution credit as follows: Video by N. Hirokawa, CC BY, first published in Cell Reports DOI 10.1016/j.celrep.2021.108971

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