Figure 1: Neuronal alteration in Tsc2+/- mice and the effect of lonafarnib administration. (IMAGE)
Caption
(A) Representative images of dendrites from mouse hippocampal neurons. Dendritic spines are longer and thinner in Tsc2+/- mice than in control mice (top right). Lonafarnib administration normalized the morphology (bottom right). (B) Neuronal activity in the hippocampus. Activated neurons are stained in black. The red lines encompass nerve cell groups in the hippocampus. In control mice, memory recall increased the number of active neurons, whereas Tsc2+/- mice had fewer active neurons (top right). Lonafarnib treatment normalized the number of activated neurons (bottom right).
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