(IMAGE)
Caption
Hematopoietic stem cells isolated from various sources such as bone marrow and umbilical cord blood are differentiated to erythroblasts, immature red blood cells that still hold a nucleus. These cells are then transduced with virus expressing HPV-E6/E7 to be immortalized. Established cell lines can be easily maintained and expanded infinitely. At a desired time, those cells are placed into a different culture condition to mature toward RBCs, which are then used for transfusion.
Credit
Dr. Kenichi Miharada
Usage Restrictions
To use this media elsewhere, the authors request that a reference to this release be included.
License
Original content