(IMAGE)

Kumamoto University

Caption

Maturation of an immortalized human erythroid cell line, ELLU, toward an enucleated reticulocyte. ELLU was established by ectopic expression of HPV-E6/E7 genes, and it wasn’t necessary to turn-off expression of those genes but rather change the culture conditions to trigger the differentiation toward mature cells. In this image, a number of ELLU cells at various stages of differentiation can be seen.

Credit

Ms. Svetlana Soboleva

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