Comparison of the conventional and the new methods (IMAGE)

Hokkaido University

Comparison of the conventional and the new methods

Caption

(Top Panel) Conventional method for synthesizing Grignard reagents by reacting magnesium and organohalides in organic solvents. This method has been used for 120 years. (Bottom Panel) New method for synthesizing Grignard reagents by mixing reactants in a ball mill with minimal organic solvent usage. This method can be used in ambient air to achieve a wide range of organic reactions with little to no solvent (Rina Takahashi, et al. Nature Communications. November 18, 2021).

Credit

Rina Takahashi, et al. Nature Communications. November 18, 2021

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