Schematic representation of the newly developed FLIM assays for mapping intranuclear variations in DNA compaction (IMAGE)

Light Publishing Center, Changchun Institute of Optics, Fine Mechanics And Physics, CAS

Schematic representation of the newly developed FLIM assays for mapping intranuclear variations in DNA compaction

Caption

(a) Schematics of labeling approaches targeting Early S- phase and Mid S-phase replicating chromatin domains. Labeling protocol was adjusted for segregation of the labeled chromosome territories to facilitate image analysis. (b) and (c) FLIM sensing of chromatin refractive index and FLIM-FRET sensing of the DNA compaction, respectively.

Credit

by Svitlana M. Levchenko, Artem Pliss, Xiao Peng, Paras N. Prasad and Junle Qu

Usage Restrictions

Credit must be given to the creator.

License

CC BY

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