Research schematic (IMAGE)

Walter and Eliza Hall Institute

Research schematic

Caption

In a healthy setting, blocking the enzyme caspase-8 results in Treg cell accumulation. But under inflammatory conditions, blocking caspase-8 triggers Treg cell death, which leads to enhanced viral clearance or autoimmunity if the cell death is excessive. Image created with BioRender.com.

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Credit: WEHI

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