Rifampicin’s effectiveness in suppressing the onset and progression of C9orf72-induced neurodegenerative diseases (IMAGE)

Osaka Metropolitan University

Rifampicin’s effectiveness in suppressing the onset and progression of C9orf72-induced neurodegenerative diseases

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Examinations of human C9orf72 gene-expressing mice show that intranasal rifampicin administration significantly inhibits the formation of RNA foci, DPR inclusions, and TDP-43 inclusions, thereby improving the mice’s cognitive functions.

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Takami Tomiyama

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