Figure 3. A neural network in the brain of a living mouse was observed without removing the skull (IMAGE)
Caption
(A). The brain’s neural network was successfully imaged using a light source in the visible wavelength region. Only the skin of a living mouse was removed and the skull was left intact. (B) Using the previous technology, it was not possible to correct the complex aberration due to the severe multiple scattered waves generated in the skull, which makes it impossible to obtain any coherent image. (C) However, the algorithm developed by the research team allowed selective removal of multiple scattering components among the reflected signal, which allows the wavefront aberration to be corrected. (D) This allowed them to resolve the fine structure of neural fibers within the brain. E, F) High-resolution projection images visualize osteocytes inside the skull of the mouse, which flourish between bone layers and dura matters and G) neural network obtained by the microscope.
Credit
Institute for Basic Science
Usage Restrictions
Attribution Required
License
Original content