Bidirectional regulation of sleep by CaMKII (IMAGE)

Japan Science and Technology Agency

Bidirectional regulation of sleep by CaMKII

Caption

The T287D mutant extends sleep duration, while mutations that do not act as phosphomimetics (T287A), and a mutation that causes loss of enzyme activity (K43R), indicating that the T287 phosphorylation and CaMKII enzyme activity is important for sleep regulation (left). Expression of a CaMKII inhibitor peptide resulted in a shortened sleep duration (right).

Credit

2022 Tone et al.

Usage Restrictions

Credit must be given to the creator.

License

CC BY

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.