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Caption
In exacerbated oral cancer cells via TGF-β-stimulated epithelial-mesenchymal transition (EMT), the amount of secreted EVs increased as compared to unstimulated oral cancer cells. TGF-β-stimulated oral cancer cell-derived EVs induced endothelial mesenchymal transition (EndoMT) in normal vascular endothelial cells to higher extent if compared with effect induced by EVs from non-stimulated oral cancer cells. In addition, the treatment of vascular endothelial sheets formed by endothelial cells with these EVs induced the formation of gaps in vascular endothelial sheet leading to increased permeability. Our results suggest that TGF-β-stimulated EMT-induced oral cancer cells contribute to cancer metastasis by secreting EVs that induce EndoMT in vascular endothelial cells and enhance vascular destabilization.
Credit
Department of Biochemistry, TMDU
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