Schematic model of how the new drug, D4, inhibits hemichannels and alleviates neuroinflammation and seizure symptoms (IMAGE)
Caption
Schematic model of how the new drug, D4, inhibits hemichannels and alleviates neuroinflammation and seizure symptoms. The new drug, D4, is a selective blocker of connexin hemichannels. Excessive glutamate and other molecules can leak out from reactive glia to the extracellular environment, altering synapses, enhancing neuroinflammation and exacerbating seizures. D4 blocks this pathway, suppresses neuroinflammation, and curbs the further development and occurrence of seizures. The latest research findings indicate that D4 is a promising candidate drug for treating epileptic seizures by targeting connexin hemichannels and neuroinflammation.
Credit
Dr Geoffrey Lau Chun-yue
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