Solving the structure of a functional amyloid protein provides new clues to the origin of a rare disease (IMAGE)

Universitat Autonoma de Barcelona

Solving the structure of a functional amyloid protein provides new clues to the origin of a rare disease

Caption

Structure of hnRNPDL-2 amyloid fibres obtained by cryoEM at 2.5 A resolution. The upper part shows the organisation of the protein with two nucleic acid binding domains in pink and a low-complexity domain responsible for its assembly. The lower part shows the cryoEM map obtained and the structure of an amyloid fibre layer and its mutations, to better understand its implication in health and disease.

Credit

IBB-UAB

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CC BY-SA

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