Figure 2: Copy number variation analysis and genetic expression analysis of BTBR/R autism model mice (IMAGE)

Kobe University

Figure 2: Copy number variation analysis and genetic expression analysis of BTBR/R autism model mice

Caption

a-c. Comparison of the repeated sequence of copy number variations, including retrovirus genes on the genome. d and e. Gene expression level analysis of repeated sequences: BTBR mice had more copy numbers of the endogenous retrovirus gene ERV than normal (B6) mice, and a portion of these genes were activated in BTBR mice.

Credit

Lin, CW., Ellegood, J., Tamada, K. et al. An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development. Mol Psychiatry (2023).

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