Roles of Itaconate in immune regulation (IMAGE)

Hokkaido University

Roles of Itaconate in immune regulation

Caption

Itaconate (ITA) inhibits the differentiation of Th17 cells and promotes the differentiation of Treg cells by inhibiting glycolysis, methionine adenosyltransferase (MAT) and isocitrate dehydrogenase (IDH1/2), which in influence expression of the cytokine IL-17A and the regulator protein FOXP3 (Michihito Kono).

Credit

Michihito Kono

Usage Restrictions

This image is copyrighted but may be used to report on this press release if credited as instructed.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.